Protagonist Therapeutics, Inc. (PTGX)

NGM – Real Time Price. Currency in USD

99.95

-3.55 (-3.43%)

At close: May 12, 2026, 4:00 PM EDT

99.80

-0.15 (-0.15%)

Pre-market: May 13, 2026, 4:59 AM EDT

12.05.2026

Tremfya, Icotyde Lead J&J's Post-Stelara Immunology Strategy

JNJ bets on Tremfya and newly approved Icotyde to drive immunology growth as Stelara faces biosimilar pressure.

05.05.2026

Protagonist Reports First Quarter 2026 Financial Results and Provides Corporate Update

ICOTYDE™ (icotrokinra) approved by FDA in March for moderate-to-severe plaque psoriasis, triggering a $50 million milestone payment; Protagonist receives tiered royalties of 6% to 10% and is eligible for up to $580 million in future milestone payments Rusfertide NDA accepted and granted Priority Review by FDA, with a Prescription Drug User Fee Act target action date in the third quarter of 2026 Protagonist exercised its rusfertide opt-out right under the Takeda collaboration on April 28, triggering a $200 million opt-out fee payable to the Company; eligible for additional $200 million opt-out and $75 million milestone payments upon NDA approval, sales milestones of up to $775 million and worldwide royalties ranging from 14% to 29% PN-881 (oral IL-17 antagonist peptide) Phase 1 study completion by mid-2026 and Phase 2 initiation anticipated by year-end; PN-477sc and PN-477o (sc and oral triple GLP/GIP/GICG agonist) Phase 1 initiation expected in mid-2026 and Q1 2027, respectively Cash, cash equivalents and marketable securities of $620 million as of March 31, 2026, anticipated to provide cash runway through at least 2028 NEWARK, CA / ACCESS Newswire / May 5, 2026 / Protagonist Therapeutics (Nasdaq:PTGX) ("Protagonist" or "the Company") today reported financial results for the first quarter ended March 31, 2026, and provided a corporate update. "The first quarter of 2026 marked a series of landmark achievements for Protagonist, highlighted by the U.S. approval of ICOTYDE, FDA granting Priority Review for rusfertide, and advancement of our highly differentiated and fully-owned peptides PN-881 and PN-477," said Dinesh V.

28.04.2026

Protagonist Exercises Rusfertide U.S. Opt-Out Right Under Takeda Collaboration

Opt-out election makes Protagonist eligible for $200 million upon exercise and an additional $200 million upon FDA approval of rusfertide for polycythemia vera Approval would also trigger a $75 million milestone payment, bringing total potential cash tied to the opt-out election and approval to $475 million Protagonist becomes eligible for up to $975 million in milestone payments and tiered royalties ranging from 14% to 29% on worldwide net sales NEWARK, CA / ACCESS Newswire / April 28, 2026 / Protagonist Therapeutics, Inc. (Nasdaq:PTGX) ("Protagonist" or the "Company") today announced that it has exercised its right to opt out of the 50:50 U.S. profit and loss sharing arrangement under its worldwide license and collaboration agreement with Takeda for rusfertide, an investigational first-in-class hepcidin mimetic peptide under U.S. Food and Drug Administration (FDA) Priority Review for the treatment of adults with polycythemia vera (PV). By exercising its opt-out right during the contractual opt-out period, Protagonist becomes eligible to receive up to $400 million in opt-out payments, consisting of $200 million payable upon the opt-out election and a further $200 million payable upon FDA approval of rusfertide for the treatment of adults with PV.

16.04.2026

Protagonist Therapeutics Reports Granting of Inducement Awards

NEWARK, CA / ACCESS Newswire / April 16, 2026 / Protagonist Therapeutics, Inc. (Nasdaq:PTGX) today reported that on April 15, 2026, it issued inducement awards to two recently hired employees in accordance with the terms of their employment offer letters. The awards were granted under the Protagonist Therapeutics Amended and Restated Inducement Plan, which was adopted May 29, 2018, and amended February 18, 2020 and February 15, 2022.

28.03.2026

Protagonist Announces Presentation of One-Year Phase 3 Data for ICOTYDE(TM) in Moderate-to-Severe Plaque Psoriasis at the 2026 American Academy of Dermatology (AAD) Annual Meeting

One-year Phase 3 data for ICOTYDE to be presented at AAD 2026 demonstrate lasting skin clearance and a favorable safety profile in a once daily pill for moderate-to-severe plaque psoriasis Results further support the differentiated profile of ICOTYDE, the first and only IL-23 receptor targeted oral peptide NEWARK, CA / ACCESS Newswire / March 28, 2026 / Protagonist Therapeutics, Inc. (Nasdaq:PTGX) ("Protagonist" or "the Company") today announced new one-year Phase 3 results for ICOTYDE™ (icotrokinra) were presented at the 2026 American Academy of Dermatology (AAD) Annual Meeting. Data from the Phase 3 ICONIC-ADVANCE 1 and 2 and ICONIC-LEAD studies further support the potential of ICOTYDE as a differentiated oral therapy for patients with moderate-to-severe plaque psoriasis.

24.03.2026

Protagonist Partners With Johnson & Johnson To Compete With AbbVie's Skyrizi

Protagonist Therapeutics earns a Buy rating, driven by Icotyde's FDA approval and robust near-term commercialization catalysts. Icotyde, the first oral IL-23 receptor antagonist for plaque psoriasis, offers best-in-class oral efficacy and placebo-like safety, with significant royalty and milestone potential. PTGX's pipeline, validated by Icotyde and Rusfertide, leverages its proprietary Vectrix platform to target obesity, hematology, and inflammation, supporting long-term value creation.

20.03.2026

Protagonist Therapeutics Stock Rallies Nearly 7% in a Week: Here's Why

PTGX stock jumps as JNJ wins FDA nod for Icotyde in plaque psoriasis, unlocking milestone payments and royalty potential for Protagonist.

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05.05.2026

Protagonist Reports First Quarter 2026 Financial Results and Provides Corporate Update

28.04.2026

Protagonist Exercises Rusfertide U.S. Opt-Out Right Under Takeda Collaboration

16.04.2026

Protagonist Therapeutics Reports Granting of Inducement Awards

28.03.2026

Protagonist Announces Presentation of One-Year Phase 3 Data for ICOTYDE(TM) in Moderate-to-Severe Plaque Psoriasis at the 2026 American Academy of Dermatology (AAD) Annual Meeting

Protagonist Therapeutics, Inc. (PTGX)

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Protagonist Therapeutics, Inc. (PTGX)

Tremfya, Icotyde Lead J&J's Post-Stelara Immunology Strategy

Protagonist Reports First Quarter 2026 Financial Results and Provides Corporate Update

Protagonist Exercises Rusfertide U.S. Opt-Out Right Under Takeda Collaboration

Protagonist Therapeutics Reports Granting of Inducement Awards

Protagonist Announces Presentation of One-Year Phase 3 Data for ICOTYDE(TM) in Moderate-to-Severe Plaque Psoriasis at the 2026 American Academy of Dermatology (AAD) Annual Meeting

Protagonist Partners With Johnson & Johnson To Compete With AbbVie's Skyrizi

Protagonist Therapeutics Stock Rallies Nearly 7% in a Week: Here's Why

Videos

No Data

Press releases

Protagonist Reports First Quarter 2026 Financial Results and Provides Corporate Update

Protagonist Exercises Rusfertide U.S. Opt-Out Right Under Takeda Collaboration

Protagonist Therapeutics Reports Granting of Inducement Awards

Protagonist Announces Presentation of One-Year Phase 3 Data for ICOTYDE(TM) in Moderate-to-Severe Plaque Psoriasis at the 2026 American Academy of Dermatology (AAD) Annual Meeting

Tremfya, Icotyde Lead J&J's Post-Stelara Immunology Strategy

Protagonist Reports First Quarter 2026 Financial Results and Provides Corporate Update

Protagonist Exercises Rusfertide U.S. Opt-Out Right Under Takeda Collaboration

Protagonist Therapeutics Reports Granting of Inducement Awards

Protagonist Announces Presentation of One-Year Phase 3 Data for ICOTYDE(TM) in Moderate-to-Severe Plaque Psoriasis at the 2026 American Academy of Dermatology (AAD) Annual Meeting

Protagonist Partners With Johnson & Johnson To Compete With AbbVie's Skyrizi

Protagonist Therapeutics Stock Rallies Nearly 7% in a Week: Here's Why

Videos

No Data

Press releases

Protagonist Reports First Quarter 2026 Financial Results and Provides Corporate Update

Protagonist Exercises Rusfertide U.S. Opt-Out Right Under Takeda Collaboration

Protagonist Therapeutics Reports Granting of Inducement Awards

Protagonist Announces Presentation of One-Year Phase 3 Data for ICOTYDE(TM) in Moderate-to-Severe Plaque Psoriasis at the 2026 American Academy of Dermatology (AAD) Annual Meeting

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Protagonist Therapeutics, Inc. (PTGX)

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Protagonist Therapeutics, Inc. (PTGX)

Tremfya, Icotyde Lead J&J's Post-Stelara Immunology Strategy

Protagonist Reports First Quarter 2026 Financial Results and Provides Corporate Update

Protagonist Exercises Rusfertide U.S. Opt-Out Right Under Takeda Collaboration

Protagonist Therapeutics Reports Granting of Inducement Awards

Protagonist Announces Presentation of One-Year Phase 3 Data for ICOTYDE(TM) in Moderate-to-Severe Plaque Psoriasis at the 2026 American Academy of Dermatology (AAD) Annual Meeting

Protagonist Partners With Johnson & Johnson To Compete With AbbVie's Skyrizi

Protagonist Therapeutics Stock Rallies Nearly 7% in a Week: Here's Why

Videos

No Data

Press releases

Protagonist Reports First Quarter 2026 Financial Results and Provides Corporate Update

Protagonist Exercises Rusfertide U.S. Opt-Out Right Under Takeda Collaboration

Protagonist Therapeutics Reports Granting of Inducement Awards

Protagonist Announces Presentation of One-Year Phase 3 Data for ICOTYDE(TM) in Moderate-to-Severe Plaque Psoriasis at the 2026 American Academy of Dermatology (AAD) Annual Meeting

Tremfya, Icotyde Lead J&J's Post-Stelara Immunology Strategy

Protagonist Reports First Quarter 2026 Financial Results and Provides Corporate Update

Protagonist Exercises Rusfertide U.S. Opt-Out Right Under Takeda Collaboration

Protagonist Therapeutics Reports Granting of Inducement Awards

Protagonist Announces Presentation of One-Year Phase 3 Data for ICOTYDE(TM) in Moderate-to-Severe Plaque Psoriasis at the 2026 American Academy of Dermatology (AAD) Annual Meeting

Protagonist Partners With Johnson & Johnson To Compete With AbbVie's Skyrizi

Protagonist Therapeutics Stock Rallies Nearly 7% in a Week: Here's Why

Videos

No Data

Press releases

Protagonist Reports First Quarter 2026 Financial Results and Provides Corporate Update

Protagonist Exercises Rusfertide U.S. Opt-Out Right Under Takeda Collaboration

Protagonist Therapeutics Reports Granting of Inducement Awards

Protagonist Announces Presentation of One-Year Phase 3 Data for ICOTYDE(TM) in Moderate-to-Severe Plaque Psoriasis at the 2026 American Academy of Dermatology (AAD) Annual Meeting